TAMIFLU Capsules 75[for treatment] 抗流感病毒剂 磷酸奥司他韦胶囊 [0114987136100251]
Price: US$344.30(tax included)
List Price: US$413.20
Weight: 100g
Item description
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. | |||||||||
| |||||||||
Effects of this medicineThis medicine blocks influenza virus from leaving the infected cell in order to suppress viral reproduction. It is usually used to treat influenza type A and type B infection. | |||||||||
Before using this medicine, be sure to tell your doctor and pharmacist
| |||||||||
Dosing schedule (How to take this medicine)
| |||||||||
Precautions while taking this medicine
| |||||||||
Possible adverse reactions to this medicineThe most commonly reported adverse reactions include diarrhea, abdominal pain and nausea. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. | |||||||||
Storage conditions and other information
|
简介:
商品名:Oseltamivir Phosphate
英文名:Tamiflu Capsules
中文名:磷酸奥司他韦胶囊
生产商:中外制药
药品简介
Tamiflu(oseltamivir phosphate)是一种抗病毒药。用于治疗A型和B型流感病毒感染的抗病毒药物。在开始使用该药物治疗之前,必须先评估肝和肾功能。这种药物不应该用于预防1岁以下儿童的流感。
タミフルカプセル75
药物类别名称
抗流感病毒剂
批准日期:2001年2月
商標名
Tamiflu Capsules
一般的名称
オセルタミビルリン酸塩(Oseltamivir Phosphate)(JAN)
药效药理
作用机理
磷酸奥司他韦的活性形式选择性抑制人甲型和乙型流感病毒的神经氨酸酶(IC50:0.1-3 nM),并抑制新形成的病毒从感染细胞中释放。抑制增长。
体外抗病毒作用
磷酸奥司他韦是一种前药,在被代谢转化为活性形式后,具有抗病毒作用。
磷酸奥司他韦的活性形式以低浓度抑制了体外甲型和乙型流感病毒的复制(实验室菌株IC50:0.6-155 nM,临床分离株IC50:<0.35μM)。
体内抗病毒作用
在小鼠和雪貂的A型和B型流感病毒感染模型中,口服奥司他韦磷酸酯(0.1-100 mg/kg/天)在存活率方面呈剂量依赖性增加,并减少与感染有关的症状。观察到诸如病毒滴度降低的治疗效果。在鸡感染模型中,观察到从病毒感染前24小时开始口服给药(1100mg/kg,每天两次)可以抑制病毒感染,例如提高存活率。
抵抗性
在国外和国内临床研究中,对该药物产生抗药性的病毒在成人和青少年(13岁及以上)中为0.67%(15 /2,253例),在幼儿(1至12岁)中为4.24%(72/1,698例)。新生儿和婴儿(1岁以下)占18.31%(13/71例)。所有抗性病毒均衍生自A型病毒,在B型病毒中未观察到出现。抗药性获得性病毒在小鼠和雪貂中的感染性降低,据认为该病毒在感染部位的生长和传播较低。在抗性病毒中发现了神经氨酸酶中的氨基酸突变。
适应症
甲型或乙型流感病毒感染及其预防
用法与用量
通常,对于体重37.5千克或以上的成人和儿童,奥司他韦以75毫克的剂量口服,每天两次,共5天。
成人
通常,每天一次口服75毫克奥司他韦,持续7至10天。
37.5公斤或以上的儿童
通常,每天一次口服75毫克奥司他韦,持续10天。
制造商
中外制药有限公司
Facebook Comments