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AZILVA Tablets 20mg 降压药 阿齐沙坦片 [0114987123152225]

AZILVA Tablets 20mg 降压药 阿齐沙坦片 [0114987123152225]

Price: US$243.60(tax included)

List Price: US$293.00

Weight: 150g

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Item description

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
AZILVA Tablets 20mg
　Active ingredient:
Azilsartan
　Dosage form:
slightly red tablet, major axis 9.1 mm, minor axis 5.1 mm, thickness about 3.3 mm
　Print on wrapping:
(Face) アジルバ, 20mg(Back) アジルバ, 20

Effects of this medicine

This medicine lowers blood pressure by reducing peripheral vascular resistance via antagonizing receptor of angiotensin II, an intrinsic substance which raises blood pressure by constricting blood vessels.
It is usually used to treat hypertension.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have a high blood potassium level, renal disorder, liver disorder, or cerebrovascular disorder.
    If you are a preoperative patient, receiving hemodialysis, or under low-salt diet treatment.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For adults: In general, take 1 tablet (20 mg of the active ingredient) at a time, once a day. The dosage should be adjusted according to your age and symptoms, but 2 tablets (40 mg) once a day is the upper limit of dosage. Strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible. However, let more than 8 hours elapse between doses. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Dizziness and light-headedness may occur due to an excessive decrease in blood pressure. Therefore, be aware of working at heights or operating dangerous machinery such as driving a car.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, eczema, itching, dizziness, headache, and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • facial/tongue/throat swelling, breathlessness [angioedema]
  • feeling cold, vomiting, falling unconscious [shock, syncope, loss of consciousness]
  • decreased urination output, swelling of face and hands/feet, fever [acute renal failure]
  • numbness of hands/feet and lips, muscle weakness [hyperkalemia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

简介

商品名：Azilva
英文名：Azilsartan
中文名：阿齐沙坦片
生产商：武田（Takeda）


药品简介
阿齐沙坦酯钾盐(azilsartan medoxomil)是日本武田研发。阿齐沙坦的一种前药，在胃肠道吸收期间被水解为阿齐沙坦。2011年2月22日在FDA批准上市，商品名：Edarbi，规格为40mg、80mg。2012年4月阿齐沙坦在日本上市，商品名：Azilva
アジルバ錠10mg/アジルバ錠20mg/アジルバ錠40mg


药物类别名称
持久性AT1受体阻滞器
批准日期：2012年4月


商標名
AZILVA Tablets

一般名
アジルサルタン（Azilsartan）〔JAN〕

 

 

药用药理学
1. 作用机制
阿迪尔沙坦是对抗血管紧张素II结合血管紧张素II型1(AT1)受体,主要是由于周围血管阻力减少引起的抑制其强大的血管收缩作用,它显示了降压作用。
2. AT1受体的抑制作用
人类AT1受体的活性以浓度依赖性的方式被抑制(IC50值:0.62~2.6nmol/L),与AT1受体的分离非常渐进(体外)。
3. 对列宁-血管紧张辛的影响
在健康成人(12例)中,每天施用阿迪尔苏丹20mg一次,7天,血浆肾素活性,血浆血管紧张素I浓度增加,血管紧张素II浓度增加。
4. 降压作用
(1)在高血压自发性大鼠(SHR)中施用一次时,抗高血压作用持续到24小时后。
(2)肾高血压(2K-1C)在狗身上施用一次时,降压作用持续到24小时后。

 

 


适应症
高血圧症

 

 


用法与用量
成人口服一次,每天20毫克。另外,年龄,但根据症状适当增加或减少,最大每日剂量为40mg。

 


制造和销售
武田制药

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