Nexium Capsules 20mg100c 高级胃药 埃索美拉唑镁胶囊 [0114987081103062]

Nexium Capsules 20mg100c 高级胃药 埃索美拉唑镁胶囊 [0114987081103062]

Price: US$190.70(tax included)

List Price: US$229.00

Weight: 40g

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Item description

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Nexium Capsules 20
 Active ingredient:
Esomeprazole magnesium hydrate
 Dosage form:
deep blue/slight yellow-red capsule, major axis: 11.40 mm, minor axis: 4.90 mm
 Print on wrapping:
(Face) ネキシウム20, (Back) Nexium 20, ネキシウム20mg, 胃酸を抑える薬

Effects of this medicine

This medicine acts on a terminal step in gastric acid secretion, called proton-pump, and inhibits gastric acid secretion. It consequently increases pH in the stomach and enhances antimicrobial actions of antibacterial agents.
It is usually used to treat gastric/duodenal/anastomotic ulcer, reflux esophagitis, Zollinger-Ellison syndrome, and for suppression of recurrence of gastric/duodenal ulcer associated with nonsteroidal anti-inflammatory drug or low-dose aspirin medication. Also, this medicine is used to help the eradication of Helicobacter pylori in the stomach in gastric/duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, after endoscopic therapy for early gastric cancer and Helicobacter pylori gastritis together with 2 other antibacterial agents.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have liver disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • To treat gastric/duodenal/anastomotic ulcer or Zollinger-Ellison syndrome: In general, for adults, take 1 capsule (20 mg of esomeprazole) at a time, once a day. The usual duration of administration is up to 8 weeks for gastric/anastomotic ulcer, and up to 6 weeks for duodenal ulcer. 
    In general, for children whose body weight is 20 kg or over, take 10 to 20 mg of esomeprazole at a time, once a day, according to the symptoms. The usual duration of administration is up to 8 weeks for gastric/anastomotic ulcer, and up to 6 weeks for duodenal ulcer.
    To treat reflux esophagitis
    : In general, for adults, take 1 capsule (20 mg of esomeprazole) at a time, once a day. The usual duration of administration is up to 8 weeks. For maintenance therapy of repeatedly recurrent/relapsing reflux esophagitis, take 10 to 20 mg of esomeprazole at a time, once a day.
    In general, for children whose body weight is 20 kg or over, take 10 to 20 mg of esomeprazole at a time, once a day, according to the symptoms. The usual duration of administration is up to 8 weeks.
    For suppression of recurrence of gastric/duodenal ulcer associated with nonsteroidal anti-inflammatory drug or low-dose aspirin medication
    : In general, for adults, take 1 capsule (20 mg of esomeprazole) at a time, once a day. 
    To help the eradication of Helicobacter pylori
    : In general, for adults, take 1 capsule (20 mg of esomeprazole) concomitantly with 750 mg of amoxicillin hydrate (titer) and 200 to 400 mg of clarithromycin (titer) at a time, twice a day, for 7 days.
    If this is insufficient, as an alternative, take 1 capsule (20 mg of esomeprazole) concomitantly with 750 mg of amoxicillin hydrate (titer) and 250 mg of metronidazole at a time, twice a day, for 7 days. 
    This preparation contains 20 mg of esomeprazole in a capsule.
    In any case, strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Pay attention when taking any food containing St. John's wort, since it may diminish medicinal effects.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, abnormal hepatic function, erosive gastritis, abdominal distension, gastric polyps, anemia, abdominal pain, photosensitivity reaction, rash, loose stool and taste abnormality. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • respiratory distress, hives, facial/lips/tongue swelling  [shock, anaphylaxis]
  • general malaise, fever, nose/subcutaneous bleeding  [pancytopenia, agranulocytosis, decreased platelets]
  • nausea/vomiting, loss of appetite, yellowing of the skin and the white of eyes [fulminant hepatitis, liver dysfunction, jaundice, hepatic failure]
  • fever, general malaise, rash/redness on the skin/eyes and in the mouth  [toxic epidermal necrolysis, muco-cutaneo-ocular syndrome]
  • fever, cough, shortness of breath  [interstitial pneumonia]
  • fever, rash, joint pain [interstitial nephritis]
  • muscle pain of limbs, rigidity, numbness, red-brown urine [rhabdomyolysis]
  • nausea/vomiting, convulsion, headache, consciousness disorder [hyponatraemia]
  • confused consciousness and unable to have normal thoughts, impaired mind, hallucination [confusional state]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

简介:

英文名:Esomeprazole Magnesium Hydrate
商品名:Nexium Capsules
中文名:埃索美拉唑镁胶囊
生产商:阿斯利康公司
ネキシウムカプセル10mg/ネキシウムカプセル20mg
药用分类名称
质子泵抑制剂
批准日期:2011年9月

 

药效药理

作用机制
通过各种酸分泌刺激剂结合到胃壁细胞细胞细胞膜上的受体,胃壁细胞中发生一系列胃酸分泌反应。 在反应的最后阶段,一种叫做质子泵的酶从胃壁细胞中释放H+,而不是吸收K+。 埃索美拉索通过抑制质子泵的工作来抑制胃酸分泌。


人类的作用
对胃pH值的影响
在健康成人中,埃索美拉索10mg,胃pH值在24小时内通过20mg和40mg施用显示4或更多的时间比例分别为48±23%、62±14%和68±8%。
在5例儿童患者中,胃pH值在12小时内通过10mg和20mg施用的4小时以上的时间百分比为51.2%至98.3%。
非临床试验的作用
质子泵抑制作用
对兔胃粘膜(H+、K+-ATPase)的质子泵表现出抑制作用。
胃酸分泌抑制作用
对分离兔胃底腺的胃酸生产有抑制作用。
在胃痉挛大鼠和海登海根Pouch犬中,对刺激剂诱导的胃酸分泌表现出抑制作用。
埃索美拉索是该制剂的活性成分,是奥美拉索(S体)的一种光学异构体,是种族。

 


适应症

胶囊20毫克
非类固醇消炎药给药期间胃溃疡或十二指肠溃疡的复发抑制
风湿性关节炎,作为长期施用非类固醇消炎药的患者,如骨关节炎疼痛管理,在开始给药时,确认胃溃疡或十二指肠溃疡的病史。
低剂量阿司匹林给药期间胃溃疡或十二指肠溃疡的复发抑制
患者继续施用低剂量阿司匹林以抑制血栓和栓塞的形成,在开始给药时,确认胃溃疡或十二指肠溃疡的病史。
幽门螺杆菌的消毒辅助
幽门螺杆菌消毒治疗进展期胃MALT淋巴瘤的有效性尚未确定。
对于特发性血小板减少性紫杉醇,参考指南等,只对幽门螺杆菌消毒治疗认为适当的病例进行消毒治疗。
除了早期胃癌的内窥镜治疗后胃外,通过幽门螺旋杆菌消毒治疗抑制胃癌发病的有效性尚未建立。
当用于幽门螺旋杆菌感染胃炎时,幽门螺杆菌被确认为阳性,并通过内窥镜检查确认幽门螺杆菌感染胃炎。

 

 

用法与用量
胶囊10毫克
胃溃疡,十二指肠溃疡,关节溃疡,佐林格-伊利森综合征
成人
通常,成人每天口服20mg作为埃索美拉索一次。 通常,胃溃疡,在关节溃疡长达8周,在十二指肠溃疡中施用长达6周。
儿童
通常,作为1岁及以上婴儿和儿童的Esomeprazole,一次10mg小于20公斤体重,10mg根据症状在体重20公斤以上,每天口服10-20mg一次。 通常,胃溃疡,在关节溃疡长达8周,在十二指肠溃疡中施用长达6周。

 


反流食管炎
成人
通常,成人每天口服20mg作为埃索美拉索一次。通常,它管理长达8周。
在维持治疗反流食管炎重复复发和复发,每天口服10至20mg。
儿童
通常,作为1岁及以上婴儿和儿童的Esomeprazole,一次10mg小于20公斤体重,10mg根据症状在体重20公斤以上,每天口服10-20mg一次。通常,它管理长达8周。

 


非侵蚀性胃食管反流病
成人
通常,成人每天口服10mg作为埃索美拉索一次。通常,它管理长达4周。
儿童
通常,作为1岁以上的婴儿和儿童的Esomeprazole,每天口服10mg一次。 通常,它管理长达4周。

 


非类固醇消炎药给药期间胃溃疡或十二指肠溃疡的复发抑制
通常,成人每天口服20mg作为埃索美拉索一次。

 


低剂量阿司匹林给药期间胃溃疡或十二指肠溃疡的复发抑制
通常,成人每天口服20mg作为埃索美拉索一次。

 


幽门螺杆菌消毒援助
通常,成人一次20mg作为埃索美拉索,一次750mg作为阿莫西林水合物(滴度)和克拉霉素一次200mg(滴度)3剂一次,每天两次,口服7天。 如有必要,克拉霉素可适当增加。 然而,一次400mg(滴度)上限为每天两次。
质子泵抑制剂,如果幽门螺杆菌的消毒治疗不成功,通过施用阿莫西林水合物和克拉霉素的三剂,作为替代治疗,通常成人一次20mg作为埃索美拉索, 一次750mg(滴度)和三剂250mg作为阿莫西林水合物,每天两次,每天两次,口服7天。
20毫克

 


胃溃疡,十二指肠溃疡,关节溃疡,佐林格-伊利森综合征
成人
通常,成人每天口服20mg作为埃索美拉索一次。通常,胃溃疡,在关节溃疡长达8周,在十二指肠溃疡中施用长达6周。
儿童
通常,在体重超过20公斤的婴儿和儿童中,作为埃索美拉索,每天口服10至20mg,视症状而成。通常,胃溃疡,在关节溃疡长达8周,在十二指肠溃疡中施用长达6周。

 


反流食管炎
成人
通常,成人每天口服20mg作为埃索美拉索一次。 通常,它管理长达8周。
在维持治疗反流食管炎重复复发和复发,每天口服10至20mg。
儿童
通常,在体重超过20公斤的婴儿和儿童中,作为埃索美拉索,每天口服10至20mg,视症状而成。通常,它管理长达8周。

 

 

非类固醇消炎药给药期间胃溃疡或十二指肠溃疡的复发抑制
通常,成人每天口服20mg作为埃索美拉索一次。
低剂量阿司匹林给药期间胃溃疡或十二指肠溃疡的复发抑制
通常,成人每天口服20mg作为埃索美拉索一次。

 


幽门螺杆菌消毒援助
通常,成人一次20mg作为埃索美拉索,一次750mg作为阿莫西林水合物(滴度)和克拉霉素一次200mg(滴度)3剂一次,每天两次,口服7天。 如有必要,克拉霉素可适当增加。 然而,一次400mg(滴度)上限为每天两次。
质子泵抑制剂,如果幽门螺杆菌的消毒治疗不成功,通过施用阿莫西林水合物和克拉霉素的三剂,作为替代治疗,通常成人一次20mg作为埃索美拉索,一次750mg(滴度)和三剂250mg作为阿莫西林水合物,每天两次,每天两次,口服7天。

 


生产商
阿斯利康

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